| May 2024 |
| Graduate Student |
Dissertation Title |
Advisor(s) |
| Avnika Bali |
A “Spicy” Molecular Mechanism of TRPA1 Hyperactivation Conferred by a Disease Mutant and Insights Into C-Terminal Regulatory Components |
Candie Paulsen |
| Kathryn Barth |
Investigating the Sequence Requirements for Specific Ligand Recognition in Variant Riboswitches |
Scott Strobel |
| Allison Butt |
The Duality of Neurons: Co-Transmission of Serotonin and a Neuropeptide, NLP-3, in the Caenorhabditis Elegans Egg-Laying Circuit |
Michael Koelle |
| Kevin Chung |
Structural Insights Into Group II Intron Splicing and Retrotransposition |
Anna Marie Pyle |
| Daisy Duan |
Regulation of Microtubule Nucleation and Repair by an Abl Family Kinase |
Anthony Koleske |
| Luka Maisuradze |
The Elucidation of Chromatin Structural Properties Through Feature Detection in Hi-C Maps |
Corey O’Hern |
| Katelyn Noronha |
Understanding Vulnerabilities in Metabolism and DNA Repair in Oncometabolite-Producing Cancers |
Ranjit Bindra |
|
Justin Sanders
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Uncovering a Critical Role for Calmodulin in Calcium-Dependent Regulation of the Nociceptor TRPA1 |
Candie Paulsen |
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| December 2023 |
| Gabriel Casanova Speúlveda |
Autoregulation Mechanism of LIM Domain Kinases |
Titus Boggon |
| Ellen Corcoran |
Disruption of Trio GEF Function and Regulation in Neurodevelopmental Disorders |
Tony Koleske |
| Daniel Konstantinovsky |
Probing Diverse Biological Systems and their Hydration Shells by Modeling Chiral Sum Frequency Generation Spectroscopy |
Sharon Hammes-Schiffer |
| May 2023 |
| Carolyn Breckel |
The Essential Protein Sts1 Facilitates 26S Proteasome Nuclear Import by a Unidirectional Mechanism in Saccharomyces cerevisiae |
Mark Hochstrasser |
| Carson Bryant |
Uncovering Novel Biological Regulators of Human Ribosome Biogenesis |
Susan Baserga |
| Peter Dahl |
Toward Understanding the Mechanism of Charge Transport in Protein Nanowires |
Nikhil Malvankar |
| Austin Draycott |
Canonical and Non-Canonical Functions of Dihydrouridine Synthases in Health and Disease |
Wendy Gilbert |
| Mason McCool |
Novel Protein Regulators of Human Ribosome Biogenesis |
Susan Baserga |
| Aldo Salazar Morales |
Molecular Mechanism of Assembly and Secretion of Geobacter sulfurreducens Pili and Cytochrome Nanowires for Extracellular Electron Transport |
Nikhil Malvankar |
| December 2022 |
| Nakeriah Christie |
Investigating a Locomotor Neuron that Makes a Potential Sensory Cilium Lying over the C. elegans Egg-laying Apparatus, Designing an Accessible System for Neuron Identifications, and Advancing Imaging and Modeling in the Egg-laying System |
Michael Koelle |
| Caroline Focht |
Monitoring Translation Regulation by Structured RNA Elements |
Scott Strobel |
| Shawn Gray |
Determining the Function and ATPase/RNA Remodeling Cycle of Dbp5 |
Enrique De La Cruz |
| Nicholas Huston |
Identifying Riboregulatory Elements in Long, Single-Stranded, Positive-Sense RNA Viral Genomes |
Anna Marie Pyle |
| Wanging Lyu |
Abl2 Regulates Microtubule Dynamics Through Interaction With Both the Microtubule Lattice and Tubulin Dimers |
Tony Koleske |
| Shivali Patel |
A Pipeline for Discovery and Determination of Functional Tertiary Structures in Large RNAs |
Anna Marie Pyle |
| Sarah Prophet |
Mechanisms of Protein Quality Control at the Nuclear Envelope and During Nuclear Pore Complex Biogenesis |
Christian Schlieker |
| Catherine Shipps |
Electrons on the Move in Proteins: Microbial Cytochrome Nanowires in Extracellular Electron Transfer and as Functional Materials |
Nikhil Malvankar |
| Vishok Srikanth |
Structural Basis for the Assembly of OmcS and OmcS-Like Cytochrome Nanowires in Diverse Microbial Species |
Nikhil Malvankar |
| Josh Zimmer |
The Dynamics of Early Steps in Transcription and Their Dysregulation in X-Linked Dystonia Parkinsonism |
Matthew Simon |
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May 2022
|
| Dahyana Arias Escayola |
Comprehensive Identification and Characterization of Cajal Body Components |
Karla Neugebauer |
| Josie Bircher |
Regulation of Trio GEF1 Activity by the Spectrin Repeats and Cellular Factors |
Tony Koleske |
| Megan Brady |
Structural Basis of Flagellar Filament Asymmetry and Supercoil Templating by Leptospira Sheath Factors |
Charles Sindelar |
| Melanie Horwitz |
Targeted Nucleic Acid Delivery to the Endothelium |
Mark W. Saltzman |
| Clorice Reinhardt |
Tyrosine Mediated Proton-Coupled Electron Transfer Reactions |
Sharon Hammes - Schiffer |
| December 2021 |
| Catherine Amaya |
Role of NOMO in Determining ER Morphology and Function |
Christian Schlieker |
| Sachita Ganesa |
The DNA Mismatch Repair Pathway Affects ATR Activation Upon Temozolomide Treatment in MGMT-Promoter Methylated Glioblastoma Multiforme |
Ranjit Bindra |
| Mengyuan (Helen) Sun |
Characterizing the Photophysics of Photoconvertible Fluorescent Protein mEos3.2 for Quantitative Fluorescence Microscopy |
Thomas Pollard & Joerg Bewersdorf |
| Joshua Temple |
Structural Studies on Mechanisms of SAMHD1 Function and Dysfunction |
Yong Xiong |
| Danielle Widner |
Novel Functions for Large Noncoding Nucleic Acids in Bacteria |
Ronald Breaker |
| May 2021 |
| Rajshekhar Basak |
Biophysical Characterization of Somatosensory Responses in Drosophila Class IV Dendritic Arborization Neurons |
Joe Howard |
| Marth Braun |
FisB Mediated Membrane Fission During Sporulation in Bacillus Subtilis |
Erdem Karatekin |
| Ken Brewer |
Computational Discovery of Structured Noncoding RNA Motifs in Bacteria |
Ronald Breaker |
| Chin Leng Cheng |
Insights Into the Regulation and Mechanism of 26S Proteasome Base Assembly in Saccharomyces Cerevisiae |
Mark Hochstrasser |
| Jennifer Garbarino |
Loss of ATRX Confers DNA Repair Defects and PARP Inhibitor Sensitivity in Glioma |
Ranjit Bindra & Ryan Jensen |
| Lisa McLean |
Discovering Novel Regulators of Nucleolar Form and Function |
Susan Baserga |
| Curran Oi |
Reversible Peptide-Protein Interactions Inside Cells: Enabling a New Approach for Achieving Super-Resolution Imaging in Live Cells |
Lynne Regan |
| Kristen Reimer |
Co-Transcriptional Splicing in Murine Erythroblasts |
Karla Neugebauer |
| Nicole Rosa Mercado |
Insights Into the Biogenesis of Stress-Induced Readthrough Transcripts |
Joan Steitz |
| Meaghan Sullivan |
A Comparative Approach to Studying RNA Biochemistry Using TimeLapse Chemistry and Labeling in Cell Culture (TILAC) |
Matthew Simon |
| Kuanlin Wu |
Platelet-Derived Growth Factor Receptor Beta Activates Abl2 Through Direct Binding and Phosphorylation |
Tony Koleske |
| December 2020 |
| Lea Kiefer |
Investigating RNA Population Dynamics Through Nucleotide Recoding: Extending the TimeLapse-seq Toolkit to 6-Thioguanosine |
Matthew Simon |
| Patrick O’Brien |
A Tale of Two Nanowires: The Biochemical and Spectroscopic Characterization of the Conductive Cytochrome OmcS and OmcZ Filaments of Geobacter Sulfurreducens |
Nikhik Malvankar |
| May 2020 |
| Tara Alpert |
Coordination Between Pre-Mrna Splicing And Cleavage In Budding Yeast |
Karla Neugebauer |
| Ryan Brecht |
Regulation And Targeting Of V(D)J Recombination Through Rag Interactome Analysis |
David Schatz |
| Hongli Chen |
A Wolbachia Nuclease And Its Binding Partner Provide A Novel Mechanism For Cytoplasmic Incompatibility |
Mark Hochstrasser |
| Edward Courchaine |
Assembly Mechanisms Of Nuclear Bodies |
Karla Neugebauer |
| Garrett Debs |
Using Cryo-Electron Microscopy To Study Microtubule Heterogeneity |
Charles Sindelar |
| Robert Fernandez |
An Atlas Of Neurotransmitter Gpcr Cellular Expression Patterns In The C. Elegans Egg-Laying Circuit |
Michael Koelle |
| Pei-Tzu Huang |
Interactions And Regulation Of The Microtubule System By Viral And Cellular Proteins |
Yong Xiong & Joe Howard |
| Andrew Huehn |
Structural Studies Of Actin-Binding Proteins Involved In Actin Dynamics, Organization And Force Sensing |
Charles Sindelar |
| Nicole Johnston |
Fluoride Toxicity And The Cellular Response In Normal, Sensitized, And Resistant Yeast |
Scott Stobel |
| Kirsten Knecht |
Investigating Immune Pathways Involved With Cancer Drug Metabolism & Viral Evasion |
Yong Xiong |
| Christopher Lim |
Structural Elucidation Of A Multifunctional Protein From Orientia Tsutsgamushi |
Yong Xiong |
| Nandan Pandit |
Mechanical Properties Of The Arp2/3 Complex |
Enrique De La Cruz |
| Jeremy Schofield |
Timelapse-Seq: Examining The Dynamics Of The Transcriptome Through 4-Thiouridine Nucleoside Recoding |
Matthew Simon |
| Juliana Shaw |
Actin Regulation And Functional Interactions In Dendritic Spines |
Anthony Koleske |
| December 2019 |
| Lauren Budenholzer |
The Protein Sts1 Binds Mature Proteasomes And Facilitates Proteasome Nuclear Localization In Saccharomyces Cerevisiae |
Mark Hochstrasser |
| Neal Ravindra |
Molecular Assembly In The Endocytic Pathway |
Julien Barro |
| Anthony Schramm |
Plastic Deformations And Fragmentation Of Deformed Actin And Cofilactin Filaments |
Enrique De La Cruz |
| Tyler Smith |
Reengineering The Uridine-54 Trna Methyltransferase, Trma, To Covalently Capture New Rna Substrates |
Matthew Simon |
| May 2019 |
| Ruben Atilho |
Using Riboswitches To Uncover Hidden Biological Processes And Novel Antibacterial Agents |
Ronald Breaker |
| Kelly Culhane |
Uncovering The Molecular Mechanisms Of Ligand Binding To Parathyroid Hormone 1 Receptor |
E. Chui - Ying Yan |
| Katherine Farley - Barnes |
Discovery Of New Regulators Of Human Ribosome Biogenesis |
Susan Baserga |
| Jimi Miller |
Canonical And Non-Canonical Plant Heterotrimeric G Proteins In Plant Immunity |
Nicole Clay |
| Stephanie Reikine |
Biophysical Studies On Nucleotide Sensing Proteins In The Immune System |
Enrique De La Cruz & Yorgo Modis |
| Michael Rutenberg Schoenberg |
Development Of Computational Tools To Analyze New Experimental Technologies For The Study Of Noncoding Rna |
Matthew Simon & Mark Gerstein |
| Sarah Smaga |
Examining The Interaction Of The Antiviral Protein Mxb With Hiv Capsid |
Xiong Yong |
| Sammie Ziegler |
Insight Into Interactions Of Apobec3 Proteins With Dna And Hiv Vif |
Xiong Yong |
| December 2018 |
| Olga Buzovetsky |
Protecting The Genome: Preserving Nucleotide Metabolism And Dna Repair, And Defending Against Viral Invaders |
Yong Xiong |
| Ethan Laudermilch |
Elucidating Torsin Atpase Function And Regulation At The Nuclear Envelope |
Christian Schlieker |
| Cary Liptak |
Investigating Nucleotide Selection Fidelity Mechanisms In Dna Polymerase Beta |
Patrick J. Loria |
| Jimi Miller |
Non-Canonical Plant G Proteins In Plant Immunity |
Nicole Clay |
| Daniel Moonan |
Design And Construction Of A Recoded Organism Containing 62 Codons |
Farren Isaacs |
| Brady Summers |
Modular Hiv-1 Capsid Assemblies For Investigating Diverse Host Recognition Mechanisms |
Yong Xiong |
| Tenaya Vallery |
Functional Studies On Polyadenylated Nuclear Rna In Kaposi’S Sarcoma-Associated Herpesvirus-Infected Cells |
Joan Steitz |
| May 2018 |
| Daniel Bondeson |
Furthering The Scope, Understanding, And Application Of Proteolysis Targeting Chimera |
Craig Crews |
| Erin Duffy |
Measuring Transcriptional Dynamics Using Mts Chemistry |
Mathew Simon |
| Michael Hinrichsen |
Applying Protein-Peptide Interactions To Fluorescently Label Proteins In S. Cerevisiae |
Lynne Regan |
| Michael Lacy |
Single-Molecule Dynamics In Clathrin-Mediated Endocytosis And Membrane Remodeling |
Julien Berro |
| Caroline Reiss |
Structural Basis for Functional Versatility in Riboswitches |
Scott Strobel |
| Madeline Sherlock |
Revealing Hidden Biology By Identifying Ligands For The Ykkc Orphan Riboswitches |
Ronald Breaker |
| Danielle Williams |
Engineering Protein-Based Biomaterials Using SpyTag/SpyCatcher Technology |
Lynne Regan |