All undergraduates, including entering freshmen (who should also meet with their college advisor), should consult one of the MB&B Faculty Advisors assigned to their class for further information, advice, and for signing their course schedules. There is no need for the DUS to sign your course schedule. Please consult the list of faculty advisors below.
Director of Undergraduate Studies (DUS)
Fall: Michael Koelle
(email to MBBUndergrad@yale.edu)
SHM CE-28A (203-737-5808)
Spring: Karla Neugebauer
(email to MBBUndergrad@yale.edu)
SHM C-123 (203-785-3322)
Majors Accepted to the B.S./M.S. Program
Faculty Advisors for Each Class Year
334A BASS (203-432-7245)
Joe Howard studied Mathematics (B.Sc., 1979) and Neurobiology (Ph.D. 1983) at the Australian National University. His interest in mechanics at the cellular and molecular scale began during postdoctoral studies in Bristol, UK and San Francisco (hair cells and hearing) and continued as a Professor at the University of Washington Medical School in Seattle (motor proteins) and as Director of the Max Planck Institute of Molecular Cell Biology & Genetics in Dresden, Germany (cytoskeletal systems). Joe’s research combines theory and experiment. He joined the Yale MB&B faculty in 2013 and holds a secondary appointment in Physics. Click here to visit his lab webpage.
236A BASS (203-432-5035)
Christian Schlieker majored in Genetics and Biochemistry at the University of Bonn, earned his PhD from the University of Heidelberg in 2004 and worked as postdoctoral fellow at Harvard Medical School and the Whitehead Institute for Biomedical Research/MIT. He joined the Yale faculty in 2009 and is now an Associate Professor in Molecular Biophysics & Biochemistry, where he investigates molecular mechanisms underlying nuclear envelopathies, using biochemical, cell biological and biophysical/structural methods. Click here to visit his lab web page.
Enrique De La Cruz
336A BASS (203-432-5424)
Enrique M. De La Cruz, Ph.D. is a Professor in the Department of Molecular Biophysics and Biochemistry at Yale University. He is a first generation Cuban-American who was raised in Newark, NJ. Dr. De La Cruz earned his Ph.D. degree in Biochemistry, Cell & Molecular Biology (BCMB) with Dr. Thomas D. Pollard at Johns Hopkins University School of Medicine and received postdoctoral training in the laboratories of Dr. H. Lee Sweeney and E. Michael Ostap at the University of Pennsylvania School of Medicine. Dr. De La Cruz has published extensively in the areas of actin and myosin regulation, RNA helicases, and signaling enzymes, for which he has received a number of awards and honors. Click here to visit his lab web page.
SHM CE25 (203-737-4752)
My group uses high-resolution structural tools, with a special emphasis on cryo-electron microscopy,(cryo-EM) to unravel the mechanism of vital biological processes. The fundamental question that drives our work is how complex formation triggers the elaborate functional activity of molecular motors and other proteins associated with biological filaments. In our cryo-EM work, we apply state-of-the-art image-processing techniques to chemical intermediates and mutant forms of enzyme complexes in order to directly visualize key conformational changes. We synthesize such data with other biochemical and biophysical data to derive mechanistic models that explain how these molecular machines work. We devote significant effort toward developing novel image-processing methods to visualize never-before-seen details of motility and other vital processes. For example, a recent breakthrough from our laboratory has allowed us to produce the first 3D reconstruction of a dimeric kinesin molecule poised in mid-step along the microtubule. This challenge was previously insurmountable due to the fact that this configuration of kinesin violates helical symmetry, combined with the small size of the kinesin. This work builds on methods which I developed during my postdoctoral studies, to identify and characterize the microtubule seam, a symmetry-violating feature of the microtubule helical lattice itself, which obstructed previous efforts to solve high-resolution cryo-EM structures of microtubules. Combining these tools along with additional innovations by ourselves and other groups, my group has worked to progressively refine our understanding of the force-generating mechanism of kinesin. We work with a number of collaborators ((Enrique De La Cruz, Albert Ko, James Rothman, David Calderwood) on other diverse processes including actin cross-linking and dissembly, flagellar motility in spirochete bacteria, SNARE-mediated fusion of synaptic vesicles and many others.
C127 SHM (203-785-4857)
Wendy Gilbert studied Molecular Biology at Princeton (AB 1994) and Biochemistry at UCSF (PhD 2004). After postdoctoral training at UC Berkeley, she joined the faculty at MIT (2008). In 2017 she moved to Yale as an Associate Professor of Molecular Biophysics and Biochemistry. Wendy is passionate about RNA Biology and about increasing diversity and inclusiveness in STEM fields. Wendy’s lab combines systems approaches, molecular genetics, and biochemistry to understand post-transcriptional gene regulation in eukaryotic cells.
Andrew Miranker studied Biology at Carnegie Mellon University, earned his PhD in Biophysics from Harvard, and did his postdoc in Biophysics at Oxford. At Yale he currently teaches MB&B 420a/720a Macromolecular Structure and Biophysical Analysis. Sporadically, he teaches MB&B 107 Being Human in STEM and MB&B 218 Art and Biomolecular Recognition. Miranker studies protein folding, misfolding and aggregation as it relates to diseases such as Alzheimer’s, Parkinson’s and Diabetes Click here to visit his webpage.
CE-28A SHM (203-737-5808)
Michael Koelle studied Mathematics and Biology at the University of Washington, earned his Ph.D. in Biochemistry from Stanford University, and received postdoctoral training in neuroscience and genetics at the Massachusetts Institute of Technology. At Yale he currently teaches MB&B 101a Biochemistry and Biophysics, as well as MB&B 300a Principles of Biochemistry I. His lab studies the mechanism neural signaling through G protein coupled receptors (GPCRs). Neurotransmitters, neuropeptides, as well as many addictive drugs act in the brain at at least in part through GPCRs that activate hetrotrimeric G proteins to modulate the activity of neurons. The Koelle lab studies the molecular mechanism of such signaling. The lab also studies how such signaling is used to control neural circuits, with these studies focused on using genetics and microscopy to analyze the egg-laying circuit of the simple nematode worm C. elegans. Click here to visit the Koelle lab webpage.