All undergraduates, including entering freshmen (who should also meet with their college advisor), should consult one of the MB&B Faculty Advisors assigned to their class for further information, advice, and for signing their course schedules. There is no need for the DUS to sign your course schedule. Please consult the list of faculty advisors below.
Director of Undergraduate Studies (DUS)
(email to MBBUndergrad@yale.edu)
BASS 318 (203-432-8954)
Majors Accepted to the B.S./M.S. Program
Faculty Advisors for Each Class Year
336A BASS (203-432-5424)
Enrique M. De La Cruz, Ph.D. is a Professor in the Department of Molecular Biophysics and Biochemistry at Yale University. He is a first generation Cuban-American who was raised in Newark, NJ. Dr. De La Cruz earned his Ph.D. degree in Biochemistry, Cell & Molecular Biology (BCMB) with Dr. Thomas D. Pollard at Johns Hopkins University School of Medicine and received postdoctoral training in the laboratories of Dr. H. Lee Sweeney and E. Michael Ostap at the University of Pennsylvania School of Medicine. Dr. De La Cruz has published extensively in the areas of actin and myosin regulation, RNA helicases, and signaling enzymes, for which he has received a number of awards and honors. Click here to visit his lab web page.
SHM CE25 (203-737-4752)
My group uses high-resolution structural tools, with a special emphasis on cryo-electron microscopy,(cryo-EM) to unravel the mechanism of vital biological processes. The fundamental question that drives our work is how complex formation triggers the elaborate functional activity of molecular motors and other proteins associated with biological filaments. In our cryo-EM work, we apply state-of-the-art image-processing techniques to chemical intermediates and mutant forms of enzyme complexes in order to directly visualize key conformational changes. We synthesize such data with other biochemical and biophysical data to derive mechanistic models that explain how these molecular machines work. We devote significant effort toward developing novel image-processing methods to visualize never-before-seen details of motility and other vital processes. For example, a recent breakthrough from our laboratory has allowed us to produce the first 3D reconstruction of a dimeric kinesin molecule poised in mid-step along the microtubule. This challenge was previously insurmountable due to the fact that this configuration of kinesin violates helical symmetry, combined with the small size of the kinesin. This work builds on methods which I developed during my postdoctoral studies, to identify and characterize the microtubule seam, a symmetry-violating feature of the microtubule helical lattice itself, which obstructed previous efforts to solve high-resolution cryo-EM structures of microtubules. Combining these tools along with additional innovations by ourselves and other groups, my group has worked to progressively refine our understanding of the force-generating mechanism of kinesin. We work with a number of collaborators ((Enrique De La Cruz, Albert Ko, James Rothman, David Calderwood) on other diverse processes including actin cross-linking and dissembly, flagellar motility in spirochete bacteria, SNARE-mediated fusion of synaptic vesicles and many others.
318 BASS (203-432-8954), Assistant Lisa Adams
Andrew Miranker studied Biology at Carnegie Mellon University, earned his PhD in Biophysics from Harvard, and did his postdoc in Biophysics at Oxford. At Yale he currently teaches MB&B 420a/720a Macromolecular Structure and Biophysical Analysis. Sporadically, he teaches MB&B 107 Being Human in STEM and MB&B 218 Art and Biomolecular Recognition. Miranker studies protein folding, misfolding and aggregation as it relates to diseases such as Alzheimer’s, Parkinson’s and Diabetes Click here to visit his webpage.
236A Bass (432-5035) Christian Schlieker majored in Genetics and Biochemistry at the University of Bonn, earned his PhD from the University of Heidelberg in 2004 and worked as postdoctoral fellow at Harvard Medical School and the Whitehead Institute for Biomedical Research/MIT. He joined the Yale faculty in 2009 and is now an Associate Professor in Molecular Biophysics & Biochemistry, where he investigates molecular mechanisms underlying nuclear envelopathies, using biochemical, cell biological and biophysical/structural methods. Click here to visit his lab web page.
CE-28A SHM (203-737-5808)
Michael Koelle studied Mathematics and Biology at the University of Washington, earned his Ph.D. in Biochemistry from Stanford University, and received postdoctoral training in neuroscience and genetics at the Massachusetts Institute of Technology. At Yale he currently teaches MB&B 101a Biochemistry and Biophysics, as well as MB&B 300a Principles of Biochemistry I. His lab studies the mechanism neural signaling through G protein coupled receptors (GPCRs). Neurotransmitters, neuropeptides, as well as many addictive drugs act in the brain at at least in part through GPCRs that activate hetrotrimeric G proteins to modulate the activity of neurons. The Koelle lab studies the molecular mechanism of such signaling. The lab also studies how such signaling is used to control neural circuits, with these studies focused on using genetics and microscopy to analyze the egg-laying circuit of the simple nematode worm C. elegans. Click here to visit the Koelle lab webpage.
234 BASS, (203) 432-5342
Candie Paulsen was raised in Portland, Oregon. She majored in Genetic Biology (B.S., 2006) at Purdue University, she earned her PhD with Dr. Kate Carroll from the University of Michigan in 2011, and worked as a postdoctoral fellow with Dr. David Julius at the University of California, San Francisco until 2017. She joined the Yale faculty in 2018 and is now an Assistant Professor in Molecular Biophysics and Biochemistry, where she investigates molecular mechanisms of pain, using biochemical, cell biological, and biophysical/structural methods.
Click here to visit the Paulsen lab webpage.
Lily Kabeche was born in Caracas, Venezuela and moved to the US at an early age. She has lived in many states including Illinois, Washington, Maryland, and Florida. Lily attended the University of Miami, where she majored in Microbiology and Immunology (B.S. 2007). She then did her Ph.D. in Biochemistry at Dartmouth College in Dr. Duane Compton’s lab, where she studied the mechanism by which kinetochore-microtubules are regulated in mitosis to promote proper chromosome segregation. She went on to do her post-doctoral work in Dr. Lee Zou’s lab, at Mass General Hospital, Harvard University, where she identified a novel role for the DNA damage repair kinase, ATR, in mitosis. She joined the Yale faculty in 2019 as an Assistant Professor in Molecular Biophysics and Biochemistry. Her current work uses a combination of cell biology, biochemistry and microscopy to investigate the non-canonical roles of the DNA damage repair pathway and to further understand the role of ATR in promoting genome stability.
Professor Simon obtained his undergraduate degree in Biochemistry at Tufts University and his Ph.D. in Chemistry from University of California at Berkeley. He did post-doctoral research at the Massachusetts General Hospital and Harvard Medical School in Boston. His research interests focus on chromatin biology and how large non-coding RNAs influence chromatin. His lab uses a combination of biochemistry, molecular biology, genomics and organic chemistry. Click here to visit his lab web page.
To schedule an appointment with professor Matt Simon, contact his assistant Paula Maher ( 737-3028)