MB&B Seminar - Paul Sigler Lecture: Eva Nogales, “Molecular regulatory mechanism of the gene silencer PRC2”

Event time: 
Monday, December 5, 2022 - 4:00pm to 5:00pm
Jane Ellen Hope Memorial Building (JEH) See map
315 Cedar Street
New Haven, CT 06510
Event description: 

PRC2 is an essential epigenetic complex during development and a major anti-cancer target. Its activity as a methyltransferase is regulated by cofactors and histone modifications, as well as automethylation. Our cryo-EM studies are providing mechanistic insights into these regulatory processes.