MB&B Seminar: “Structures and functions of nonribosomal peptide synthetases, macromolecular nanofactories”

Event time: 
Monday, April 16, 2018 - 4:00pm to 5:00pm
Bass Center for Molecular and Structural Biology (BASS) See map
266 Whitney Avenue
New Haven, CT 06511
Event description: 

Nonribosomal peptide synthetases (NRPSs) are true macromolecular machines, having modular assembly-line logic, a complex catalytic cycle, moving parts and many active sites. NRPS products include classics therapeutics (penicillin, cyclosporin, and modern billion-dollar antibiotics (daptomycin) and anti-cancer agents (dactinomycin). We have performed structural and functional analyses of components of the NRPS systems responsible for the syntheses of the antibiotic gramicidin, the siderophore bacillibactin and the anti-algae bacillamide. I will discuss results from these studies and the insight they provide into the superdomain and supermodular architecture, conformational changes and mechanisms of tailoring NRPSs use to synthesize their important bio-active products

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