March 2025 News

Comparison with cryo-EM-derived CD map and XFEL-derived omit ED maps for metal cluster of 2F PSII. (A) The emd50019 derived CD map without any map sharpening contoured at 1.3σ is superimposed on its 9evx model. (B) The OEC-omit σA-weight 2Fo−Fc map contoured at 1.0 σ is superimposed onto the single-conformation model of the 6jll/2F dataset. (C) Stereodiagram of superposition of the two maps with the 9evx model. (D) Stereodiagram of superposition of the two atomic models. (E and F) Thin slice of 1B and in a 45°-rotated view. (G) At reduced 0.5σ contouring and thin slice of 1B.

Congratulations to Jimin Wang and his recent publication in PNAS: “Cryo-EM meets crystallography: a model-independent view of the heteronuclear Mn4Ca cluster structure of photosystem II”!

March 21, 2025

Read more here: https://www.pnas.org/doi/10.1073/pnas.2423012122.

Congratulations to Isabel Romov (Paulsen Lab) who won a Student Research Achievement Award at the 2025 Biophysical Society Meeting!

March 8, 2025

The title of Isabel’s poster was, “Elucidating the molecular and structural mechanisms of a TRPA1 channelopathic mutation”.

Tang Lab Discovers How a Naturally Occurring Mechanism Hampers Fertility

March 6, 2025

Read the Yale News writeup here: https://news.yale.edu/2025/03/03/scientists-discover-how-naturally-occurring-mechanism-hampers-fertility.