Congratulations to Kimberly Wei and Anna-Sophia Boguraev, recipients of the 2020 Paul Sigler Prize. The prize was founded in Paul’s memory in 2001. Paul Sigler was a distinguished member of the faculty in the Department of Molecular Biophysics and Biochemistry and a world leader in the structural biology governing control of gene expression, transmembrane signaling, and chaperonin assisted protein folding.
Professor Michael Koelle, Kimberly’s advisor wrote:
Professor Dan DiMaio, Anna-Sophia’s advisor wrote:
“Well before joining my lab, Anna-Sophia had dreamed of space and even participated in NASA’s Genes in Space program, launching a PCR experiment onto the International Space Station. In my lab, she conducted experiments with highly simplified artificial proteins to uncover the rules governing transmembrane protein interactions. When the COVID-19 pandemic forced her to curtail her experiments, she immediately sought to invent a new avenue of analysis. A double major in English, it was no surprise to me that she applied the tools of computational linguistics to make new insights about these interactions. This was a refreshing and innovative approach, which we hope to continue to exploit after her departure. Anyone wanting to carry this project forward should be warned, studying transmembrane protein interactions is rocket science!”
|Paul Sigler (1934-2000) https://tinyurl.com/PaulSiglerObit|